Year

Authors

Methods

Participants

Location

Response

Duration

Results

1992

Pilowsky et al.

Retrospective practice-based

Doctors and nurses

South London, UK

95%

6 months

Mean doses of parenteral antipsychotics and sedatives exceeded BNF* recommendations.

1994

Cunnane et al.

Retrospective vignette-based

General adult consultants

Oxford, UK

68%

Not mentioned

No clear consensus. Chlorpromazine preferred over haloperidol. IM route favoured.

1996

Simpson et al.

Retrospective vignette-based

Consultants and registrars

Manchester, UK

67%

Not mentioned

Haloperidol preferred to chlorpromazine. BNF maximum doses felt to be inadequate to control severe aggression.

1997

Mannion et al.

Retrospective practice-based

Psychiatry trainees

Dublin, Ireland

80%

6 months

High dose antipsychotics and IM routes preferred. Zuclopenthixol acetate used in nearly half the incidents.

1998

Hyde et al.

Retrospective practice-based

Nurse-based computerised database

Manchester, UK

100%

24 months

Zuclopenthixol or haloperidol + lorazepam IM preferred. Higher doses used in disturbed or resistant cases.

1999

Binder et al.

Retrospective practice-based

Medical directors of emergency settings

USA-wide

100%

1 month

Haloperidol-lorazepam combination favoured. IM route preferred.

1999

Moritz et al.

Prospective practice-based

100 consecutive patients in emergency room

Rouen, France

100%

9 months

Intramuscular loxapine was the preferred drug of choice.

2002

Huf et al.

Retrospective practice-based

Practitioners in psychiatric emergency room

Rio de Janeiro, Brazil

100%

1 week

Haloperidol-promethazine combination preferred by 83% of participants.

2003

Reid et al.

Retrospective practice-based

Consultants

West Scotland, UK

84%

Not mentioned

Droperidol perceived to be more effective than haloperidol or chlorpromazine Disapproval at its withdrawal.

2005

Pereira et al.

Retrospective practice-based

Consultants and trainees

UK-wide

22%

Not mentioned

Lorazepam and haloperidol favoured with most doses exceeding BNF limits. Chlorpromazine, zuclopenthixol and droperidol next in line.