Year | Authors | Methods | Participants | Location | Response | Duration | Results |
1992 | Pilowsky et al. | Retrospective practice-based | Doctors and nurses | South London, UK | 95% | 6 months | Mean doses of parenteral antipsychotics and sedatives exceeded BNF* recommendations. |
1994 | Cunnane et al. | Retrospective vignette-based | General adult consultants | Oxford, UK | 68% | Not mentioned | No clear consensus. Chlorpromazine preferred over haloperidol. IM route favoured. |
1996 | Simpson et al. | Retrospective vignette-based | Consultants and registrars | Manchester, UK | 67% | Not mentioned | Haloperidol preferred to chlorpromazine. BNF maximum doses felt to be inadequate to control severe aggression. |
1997 | Mannion et al. | Retrospective practice-based | Psychiatry trainees | Dublin, Ireland | 80% | 6 months | High dose antipsychotics and IM routes preferred. Zuclopenthixol acetate used in nearly half the incidents. |
1998 | Hyde et al. | Retrospective practice-based | Nurse-based computerised database | Manchester, UK | 100% | 24 months | Zuclopenthixol or haloperidol + lorazepam IM preferred. Higher doses used in disturbed or resistant cases. |
1999 | Binder et al. | Retrospective practice-based | Medical directors of emergency settings | USA-wide | 100% | 1 month | Haloperidol-lorazepam combination favoured. IM route preferred. |
1999 | Moritz et al. | Prospective practice-based | 100 consecutive patients in emergency room | Rouen, France | 100% | 9 months | Intramuscular loxapine was the preferred drug of choice. |
2002 | Huf et al. | Retrospective practice-based | Practitioners in psychiatric emergency room | Rio de Janeiro, Brazil | 100% | 1 week | Haloperidol-promethazine combination preferred by 83% of participants. |
2003 | Reid et al. | Retrospective practice-based | Consultants | West Scotland, UK | 84% | Not mentioned | Droperidol perceived to be more effective than haloperidol or chlorpromazine Disapproval at its withdrawal. |
2005 | Pereira et al. | Retrospective practice-based | Consultants and trainees | UK-wide | 22% | Not mentioned | Lorazepam and haloperidol favoured with most doses exceeding BNF limits. Chlorpromazine, zuclopenthixol and droperidol next in line. |